San Francisco 49ers-Arizona Cardinals odds, picks and predictions

The San Francisco 49ers and Arizona Cardinals will square off in an NFC West divisional showdown on Sunday.

Following two tough road losses, the 49ers got back on the winning track last week with a blowout win over the New England Patriots. San Francisco is trying to keep pace with the division leading Seattle Seahawks, who it trails by one game. The Cardinals are sitting at 1-3 after back-to-back losses and are in danger of the season slipping through their fingers with a loss this week.

Let's take a look at the odds and best bets for this game.

49ers-Cardinals odds

Moneyline

49ers: -360
Cardinals: +280

With the 49ers getting healthier and playing at home, it's hard to imagine them dropping this game to an inconsistent Cardinals team. However, the wager isn't going to be worth the potential gain. AVOID THE MONEYLINE.

Spread

49ers: -7.5
Cardinals: +7.5

Although I like S.F. to get the win, divisional games are always tough and Arizona is desperate. Since we're avoiding the moneyline, the best bet is to PICK THE CARDINALS TO BEAT THE SPREAD.

OVER/Under 49.5 points

Over: -112
Under: -108

I can envision both of these talented offenses heating up and trading blows late in the game. BET OVER 49.5 (-112) 

Final score prediction: 49ers 31, Cardinals 27

It will be a valiant effort from the Cardinals, but they're not ready to storm into S.F. and pull an upset victory. The Niners are just too good and too experienced, and are on a four-game winning streak against Arizona.

Prop bets

QB Kyler Murray OVER 1.5 touchdown passes (+125)

Murray will be looking to keep pace with the 49ers' offense and has plenty of weapons at his disposal. He shouldn't have a problem tossing a couple of touchdown passes in the one. 

Winning margin

This is a prop bet that pays out nicely even if you wage a small amount. I like picking the Niners to win by a 1-6 point margin at +290.